Clinical trial update.

 Clinical Trial Update: November 2002  Company *                 Product (Country; Symbol)  AUTOIMMUNE  Biogen Inc.               Amevive (BGEN)      Serono SA                 Rebif (NYSE:SRA) and            (FDA-approved) Pfizer Inc.     Teva                      Copaxone Pharmaceutical            (FDA-approved) Industries Ltd. (Israel; TEVA)  CANCER  AltaRex Corp.             OvaRex MAb (Canada; TSE:AXO)      Aton Pharma               SAHA Inc. *          Biomira Inc.              BLP25 (Canada; BIOM; TSE:BRA)       Celgene Corp.             Revimid (CELG)     Cell                      Trisenox Therapeutics              (FDA-approved) Inc. (CTIC)  Cell                      Xyotax Therapeutics Inc. (CTIC)      Cell                      Xyotax Therapeutics Inc. (CTIC)   Cell                      Xyotax Therapeutics Inc. (CTIC)     EntreMed Inc.             ENMD 0995 (ENMD)   Essential                 ETRX 101 Therapeutics Inc. (ETRX)   Eximias                   Thymitaq Pharmaceutical Corp. *   FeRx Inc. *               --        Genta Inc. (GNTA)         Genasense and Aventis SA (Germany)   Genta Inc.                Genasense (GNTA)     GenVec Inc.               TNFerade (GNVC)     GenVec Inc.               TNFerade (GNVC)     Genzyme                   -- Molecular Oncology (GZMO)  Immuno-Designed           Uvidem Molecules SA * (France)    ImmunoGen Inc.            huN901-DM1 (IMGN) and British Biotech plc (UK; BBIOY; LSE:BBG)  Kosan Biosciences         KOS-862 Inc. (KOSN) and F. Hoffmann-La Roche Ltd. (Switzerland)  Maxim                     Ceplene Pharmaceuticals Inc. (MAXM)       Millennium                MLN2704 Pharmaceuticals Inc. (MLNM) and BZL Biologics LLC *       NeoPharm Inc.             IL13-PE38 (NEOL)     NeoPharm Inc.             LE-SN38 (NEOL)   NewBiotics Inc. *         Thymectacin    Onyx Pharmaceuticals      BAY 43-9006 Inc. (ONXX) and Bayer Corp.       Pharmagenesis Inc. *      PG490-88Na    Progen Industries         PI-88 (Australia; PGLAF)     Telik Inc.                TLK286 (TELK)      Telik Inc.                TLK286 (TELK)     Telik Inc.                TLK286 (TELK)      Transgene SA              MVA-Mucl- (France: TRGNY)           interleukin-2                           vaccine     CARDIOVASCULAR  Alexion                   Pexelizumab Pharmaceuticals Inc. (ALXN)    Alteon Inc.               ALT-711 (AMEX:ALT)   CollaGenex                Periostat Pharmaceuticals           (FDA-approved) Inc. (CGPI)    Carvas International      rNAPc2 Inc. (CVAS)   CV Therapeutics Inc.      CVT-3146 (CVTX)    CV Therapeutics Inc.      Tecadenoson (CVTX)   GenVec Inc.               Biobypass (GNVC)     Genzyme Biosurgery        -- (division of Genzyme Corp.: GENZ) Millennium                Integrillin Pharmaceuticals           (FDA-approved) Inc. (MLNM)      The Medicines             Angiomax Company Inc. (MDCO)       (FDA-approved)         United Therapeutics       Remodulin Corp. (UTHR)              (FDA-approved)    Vasogen Inc.              -- (Canada; AMEX:VSV; TSE:VAS)  CENTRAL NERVOUS SYSTEM  Aderis                    Rotigotine CDS Pharmaceuticals Inc. *    Avanir                    Neurodex Pharmaceuticals Inc. (AMEX:AVN)   CeNeS                     M6G Pharmaceuticals plc (UK; LSE:CEN)     DOV                       Ocinaplon Pharmaceutical Inc. (DOVP)  Guilford                  GPI 1485 Pharmaceuticals Inc. (GLFD)  Neurocrine                Indiplon-IR Biosciences Inc. (NBIX)     Neurogen Corp. (NRGN)     NGD 97-1       NeuroSearch A/S *         NS2330 (Denmark) and Boehringer Ingelheim International GmbH (Germany)  Oxford                    OGT 923 GlycoSciences plc (UK; OGSI; LSE:OGS)  Repligen                  RG1068 Corp. (RGEN)     DIABETES  Theratechnologies Inc.    ThGRF (Canada; TSE:TH)    INFECTION  Acambis plc               ChimeriVax-DEN2 (UK; LSE:ACM)   AuRx Inc. *               --        BioMarin                  Aldurazyme Pharmaceutical Inc. (BMRN) and Genzyme General (GENZ)  Gilead Sciences           Hepsera Inc. (GILD)               (FDA-approved)        Hollis-Eden               HE2000 Pharmaceuticals Inc. (HEPH)     Human Genome              Albuferon-alpha Sciences Inc. (HGSI)    Idenix                    Telbivudine Pharmaceuticals Inc. *     Immtech                   DB289 International Inc. (IMMT)  Inspire                   INS365 Pharmaceuticals           Respiratory Inc. (ISPH) Inspire                   INS37217 Pharmaceuticals Inc. (ISPH)     Inspire                   INS37217 Pharmaceuticals Inc. (ISPH     Intercell AG *            -- (Austria)  Isis                      ISIS14803 Pharmaceuticals Inc. (ISIS)      Ribapharm Inc.            Viramidine (NYSE:RNA)   Romark                    Nitazoxanide Laboratories *      SciClone                  Zadaxin Pharmaceuticals Inc. (SCLN)      Trimeris Inc. (TRMS)      Fuzeon          Vertex                    GW433908 Pharmaceuticals Inc. (VRTX)     MISCELLANEOUS  Adolor Corp.              Alvimopan (ADLR)       Alexion                   Eculizumab Pharmaceuticals Inc. (ALXN)       Amgen Inc.                Aranesp (AMGN)                    (FDA-approved)    AnorMED Inc.              Fosrenol (Canada; TSE: AOM)   AVI BioPharma             AVI-4126 Inc. (AVII)  Exhale                    ETX-100 Therapeutics Inc. *  Galileo                   GLI-8545 Laboratories Inc. *   GenVec Inc. (GNVC)        AdPEDF    Hemosol Inc.              Hemolink (Canada; HMSL TSE: HML)  Inflazyme                 IPL512,602 Pharmaceuticals Ltd. (Canada; TSE:IZP) and Aventis Pharma AG (Germany)  Isis                      ISIS 2302 Pharmaceuticals Inc. (ISIS)  Novactyl Inc. *           PCL-016    SR Pharma plc             SRP299 (UK; LSE:SPA) and Genesis Research and Development Corp. (New Zealand; ASX:GEN)  Sucampo                   RU-0211 Pharmaceuticals Inc. *  Transkaryotic             Replagal Therapies Inc. (TKTX)    Vivus Inc. (VVUS)         TA-1790     Vivus Inc. (VVUS)         VI-0162   Company *                 Description (Country; Symbol)  AUTOIMMUNE  Biogen Inc.               Alefacept; novel (BGEN)                    immuno-modulatory                           agent that                           selectively targets                           the CD45RO+ subset                           of T cells  Serono SA                 Interferon beta-la (NYSE:SRA) and Pfizer Inc.     Teva                      Oral formulation of Pharmaceutical            glatiramer acetate Industries Ltd. (Israel; TEVA)  CANCER  AltaRex Corp.             Immunotherapeutic; (Canada; TSE:AXO)         oregovomab; a fully                           foreign monoclonal                           anti-body that                           targets CA125   Aton Pharma               An inhibitor of Inc. *                    histone deacetylase          Biomira Inc.              Synthetic MUCI (Canada; BIOM;            therapeutic vaccine TSE:BRA)                  consisting of the                           25-amino-acid                           sequence of the MUCI                           cancer mucin,                           encapsulated in                           liposomes  Celgene Corp.             Orally available (CELG)                    agent;                           immunomodulatory                           drug   Cell                      Arsenic trioxide Therapeutics Inc. (CTIC)  Cell                      Links paclitaxel, the active Therapeutics …